Neurotoxicology

Tjalkens: Environmental exposure to heavy metals such as manganese is associated with neurological dysfunction in humans, particularly in children. To understand the basis for these effects, we are examining mechanisms of manganese neurotoxicity and neuroinflammatory injury in the developing mouse brain and in primary cultured glial cells.

Moreno JA, Streifel KM, Sullivan KA, Legare ME Tjalkens RB. Developmental exposure to manganese (Mn) increases adult susceptibility to inflammatory activation of glia and neuronal protein nitration. Toxicol Sci. 112, 405-415 (2009) PMID: 19812365

Moreno JA, Sullivan KA, Carbone DA, Hanneman WH, Tjalkens RB. Manganese potentiates NF-κB-dependent expression of nitric oxide synthase 2 in astrocytes by activating soluble guanylate cyclase and extracellular regulated kinase signaling pathways J. Neurosci. Res. 86:618–629 (2008) PMID: 18335517