Neurorehabilitation is the application of a variety of intervention methods to improve the condition of patients with nervous system disorders. The major neurological deficits treated at the CSU laboratories are stroke, Parkinson’s disease and those resulting from certain traumatic brain injuries.


Malcolm: We develop and investigate novel movement-based intervention to improve upper limb functional use post-stroke.  Interventions are grounded in principles of motor learning and motor control.  We apply kinematic motion analysis, functional assessments, and neurophysiological measurements to track recovery on multiple levels.

Malcolm MP, Massie C, Thaut M.  Rhythmic auditory-motor entrainment improves hemiparetic arm kinematics during reaching movements: A pilot study.  Topics in Stroke Rehabilitation 16,  69-79 (2009).   

Massie C, Malcolm MP, Greene D, Thaut M. The effects of constraint-induced therapy on kinematic outcomes and compensatory movement patterns.  Archives of Physical Medicine and Rehabilitation  99, 571-579 (2009).



Thaut: At the Center for Biomedical Research in Music we study auditory rhythm processing as a model for temporal information processing in the brain using fMRI, PET, EEG, and MEG. Our second emphasis is translational clinical research studying music and rhythm as tools to retrain brain injuries in neurorehabilitation.

Thaut  MH, Stephan KM, Wunderlich G, Schicks W, Tellmann L, Herzog H, McIntosh GC, Seitz RJ, Hömberg V.Distinct cortico-cerebellar activations in rhythmic auditory motor synchronization. Cortex 45, 44-53 (2008)  

Thaut  MH,  Gardiner JC, Holmberg D, Horwitz J, Kent L, Andrews G, Donelan B, McIntosh GR. Neurologic music therapy improves executive and psychosocial function in traumatic brain injury rehabilitation. Ann New York Acad Sci 1169, 406-416 (2009)  

Thaut  MH, Leins AK, Rice RR, Argstatter H, Kenyon GP, McIntosh GC, Bolay HV, Fetter M. Rhythmic auditory stimulation improves gait more than NDT/Bobath training in near ambulatory patients early post stroke: a single blind randomized control trial. Neurorehabil Neural Repair  21, 455-459 (2007)